A sobering podcast! What!? Oh come on, fish, barrel, slow moving target, what’s one to do.

Some really good information, but was genuinely surprised that cold fresh air did not have any physiologic effect, even if only in the mind of the drinker.

I was a little surprised to hear Dr. Tarzwell recommend Tylenol. Both are detoxified using the same cytochrome p450 and co-application can produce hepatotoxic metabolites. One study even shows that cessation of alcohol use while using acetominophen makes the breakdown of acetominophen even more toxic due to increased levels of the enzyme due to usual alcohol use. Some studies recommend no acetominphen use by those that regularly use alcohol. There is a rich literature on this that is too extensive to footnote here, so do the homework...

The effects of alcohol on acetaminophen toxicity are complicated, as both acute and chronic consumption (of both products) have to be examined. There's a good discussion in the comments of a blog post I did at Science-Based Medicine, starting with this comment:

http://www.sciencebasedmedicine.org/?p=5062#comment-51298